- RMV-7 (See other available formats)
- Regulatory Status
- Other Names
- αV integrin, Vitronectin Receptor, Integrin αV chain, ITGAV
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αv integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.Product Details
- Antibody Type
- Host Species
- BALB/c mouse IL-2-activated killer (LAK) cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP, Block - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation1, and blocking1-3 of CD51 adhesion and LAK cell cytotoxicity. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 104109 & 104110).
(PubMed link indicates BioLegend citation)
- Takahashi K, et al. 1990. J. Immunol. 145:4371. (IP Block)
- Narumiya S, et al. 1994. Int. Immunol. 6:139. (Block)
- Piali L, et al. 1995. J. Cell Biol. 130:451. (Block)
- Delpino MV, et al. 2012. J. Leukoc Biol 91:285. PubMed.
- Product Citations
AB_313071 (BioLegend Cat. No. 104102)
- Integrin family, associates with integrins β1, β3, β5 or β6, 140 kD
Activated T cells, polymorphonuclear granulocytes, blastocysts, osteoclasts
- Fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31
- Cell Type
- Granulocytes, Mesenchymal Stem Cells, Osteoclasts, T cells
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Maxfield SR, et al. 1989. J. Exp. Med. 169:2173.
3. Piali L, et al. 1995. J. Cell Biol. 130:451.
- Gene ID
- 16410 View all products for this Gene ID
- View information about CD51 on UniProt.org
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