Purified anti-mouse CD51 Antibody

Pricing & Availability
Clone
HMαV-1 (See other available formats)
Regulatory Status
RUO
Other Names
αv integrin, Vitronectin Receptor, Integrin αv chain, ITGAV
Isotype
Armenian Hamster IgG
Ave. Rating
Submit a Review
Product Citations
publications
HMalphaV-1_PURE_Integrin_Alpha_V_Antibody_1_060917
C57BL/6 mouse bone marrow cells were stained with CD51 (clone HMαV-1) (filled histogram) or Armenian Hamster IgG isotype control (open histogram), followed by goat-anti-hamster (Armenian) IgG FITC.
  • HMalphaV-1_PURE_Integrin_Alpha_V_Antibody_1_060917
    C57BL/6 mouse bone marrow cells were stained with CD51 (clone HMαV-1) (filled histogram) or Armenian Hamster IgG isotype control (open histogram), followed by goat-anti-hamster (Armenian) IgG FITC.
Cat # Size Price Quantity Check Availability Save
153202 500 µg $195.00
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αv integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Affinity-purified αVβ3
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.1 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2687270 (BioLegend Cat. No. 153202)

Antigen Details

Structure
Integrin family, associates with integrins β1, β3, β5 or β6, 140 kD
Distribution

Activated T cells, polymorphonuclear granulocytes, blastocysts, osteoclasts

Function
Adhesion
Ligand/Receptor
Fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31.
Cell Type
T cells, Granulocytes, Osteoclasts
Biology Area
Cell Adhesion, Cell Biology, Immunology, Costimulatory Molecules
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Maxfield SR, et al. 1989. J. Exp. Med. 169:2173.
2. Piali L, et al. 1995. J. Cell Biol. 130:451.

Gene ID
16410 View all products for this Gene ID
UniProt
View information about CD51 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 0    Revision Date: 06/12/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Insert Note Here
Save Close Clear
Lab Timer
Tools
Login/Register
Remember me
Forgot your password? Reset Password
Request an Account