- HMαV-1 (See other available formats)
- Regulatory Status
- Other Names
- αv integrin, Vitronectin Receptor, Integrin αv chain, ITGAV
- Armenian Hamster IgG
- Ave. Rating
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- Product Citations
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CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αv integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- Affinity-purified αVβ3
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.1 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2687270 (BioLegend Cat. No. 153202)
- Integrin family, associates with integrins β1, β3, β5 or β6, 140 kD
Activated T cells, polymorphonuclear granulocytes, blastocysts, osteoclasts
- Fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31.
- Cell Type
- T cells, Granulocytes, Osteoclasts
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Costimulatory Molecules
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Maxfield SR, et al. 1989. J. Exp. Med. 169:2173.
2. Piali L, et al. 1995. J. Cell Biol. 130:451.
- Gene ID
- 16410 View all products for this Gene ID
- View information about CD51 on UniProt.org
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