Purified anti-mouse CD365 (Tim-1) Antibody

Pricing & Availability
RMT1-4 (See other available formats)
Regulatory Status
Other Names
T cell immunoglobulin and mucin domain containing protein-1, T cell and airway phenotype regulator (Tapr), hepatitic virus cellular receptor 1, CD365
Rat IgG2b, κ
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Product Citations
Mouse Tim-1 transfected cells stained with purified anti-mouse CD365 (Tim-1, clone RMT1-4), followed by anti-rat IgG FITC
  • RMT1-4_Purified_091207
    Mouse Tim-1 transfected cells stained with purified anti-mouse CD365 (Tim-1, clone RMT1-4), followed by anti-rat IgG FITC
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119502 500 µg $335.00
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CD365 (Tim-1) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4+ lymphocytes especially on Th2 cells and has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation.  Tim-1 is an endogenous ligand for LMIR5/CD300b.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Meyers JH, et al. 2005. Nat. Immunol. 6:455.
  2. Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
  3. Yamanishi Y, et. al. 2010. J. Exp. Med. 207:1501. (FC)
  4. Namavari A, et al. 2012. Invest Ophthalmol Vis Sci. 53:4575. PubMed.
Product Citations
  1. Xiao S, et al. 2012. Proc Natl Acad Sci U S A. 109:12105. PubMed
AB_345368 (BioLegend Cat. No. 119502)

Antigen Details

Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD.

Developmentally regulated; highly expressed in embryonic development in blastocysts. Expressed on activated CD4+ lymphocytes, especially Th2 cell lines.

Binds hepatitis virus, may play a critical role in immune responses and the development of atopic diseases (in particular airway hyperreactivity).
Binds hepatitis A virus in humans, Tim-4, LMIR5/CD300b
Cell Type
T cells, Th2
Biology Area
Immunology, Inhibitory Molecules
Molecular Family
CD Molecules
Antigen References

1. McIntire JJ, et al. 2001. Nature Immunol. 2:1109.
2. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
3. Wills-Karp M, et al. 2001. Nat. Rev. Immunol. 1:69.
4. Meyers JH, et al. 2005. Nat. Immunol. 6(5):455.

Gene ID
171283 View all products for this Gene ID
View information about CD365 on UniProt.org

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Go To Top Version: 3    Revision Date: 01/14/2015

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