- 16A11 (See other available formats)
- Regulatory Status
- Other Names
- KLRC1, NKG2B, NKG2AB6
- Mouse IgG2b, κ
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- Product Citations
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CD159a, also known as NKG2A or KLRC1 (killer cell lectin-like receptor subfamily C, member 1), is a 43 kD type II transmembrane protein with extracellular C-type lectin domains. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and activated CD8+ T cells. NKG2A binds to non-classical MHC class I molecule Qa-1 and causes inhibition of NK cell-mediated target-cell lysis.Product Details
- Antibody Type
- Host Species
- C57BL/6 mouse CD94/NKG2A transfected CHO cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use licenses cannot be guaranteed from the University of California.
(PubMed link indicates BioLegend citation)
- McMahon CW, et al. 2002. J. Immunol. 169:1444. (FC)
- Vance RE, et al. 2002. P. Natl. Acad. Sci. USA 99:868. (FC)
AB_11124347 (BioLegend Cat. No. 142802)
- Type II transmembrane protein with extracelluar C-type lectin domains, complexed with CD94; 43 kD
NK cells and NK T cells from C57BL/6 mouse
- Inhibitory activity via ITIMs
- Non-classical MHC-I molecule Qa-1
- Cell Type
- Embryonic Stem Cells, Mesenchymal Stem Cells, NK cells, NKT cells
- Biology Area
- Cell Biology, Immunology, Signal Transduction, Stem Cells
- Molecular Family
- CD Molecules, MHC Antigens
- Antigen References
1. Vance RE, et al. 1998. J. Exp. Med. 188:1841.
2. Lohwasser S, et al. 1999. Eur. J. Immunol. 29:755.
3. Sivakumar PV, et al. 1999. J. Immunol. 162:6976.
4. Silver ET, et al. 1999. Immunogenetics 49:727.
5. Vance RE, et al. 1999. J. Exp. Med. 190:1801.
- Gene ID
- 16641 View all products for this Gene ID
- View information about CD159a on UniProt.org
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