- BV13 (See other available formats)
- Regulatory Status
- Other Names
- Vascular endothelial-cadherin
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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CD144, also known as vascular endothelial-cadherin (VE-cadherin), is a 120 kD member of the type II Cadherin family. It is an endothelial specific hemophilic adhesion molecule involved in endothelial cell survival, migration, contact-dependent growth inhibition, and homophilic adhesion. VE-cadherin is essential for maintaining the integrity of the endothelial barrier in vivo.Product Details
- Antibody Type
- Host Species
- VE-cadherin-Ig fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
WB, ICC, Block - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone BV13 recognizes an epitope between aa 45 and 56, and has a binding affinity of 5-15 nM5. Additional reported applications (for relevant formats) include: Western blotting1, blocking of cell interactions in vivo1, and immunofluorescence microscopy staining4.
(PubMed link indicates BioLegend citation)
- Corada M, et al. 1999. P. Natl. Acad. Sci. USA 96:9815. (WB, Block)
- Liao F, et al. 2000. Cancer Res. 60:6805. (FC)
- Crosby CV, et al. 2005. Blood 105:2771. (FC)
- Liao F, et al. 2002. Cancer Res. 62:2567. (IF)
- May C, et al. 2005. Blood 105:4337. (epitope)
- Product Citations
AB_10570497 (BioLegend Cat. No. 138001)
AB_10569559 (BioLegend Cat. No. 138002)
- A 120 kD member of type II Cadherin family
- Involved in endothelial cell survival, migration, contact-dependent growth inhibition, and hemophilic adhesion
- Cell Type
- Endothelial cells, Mesenchymal Stem Cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Allport JR, et al. 2002. J. Leukocyte Biol. 71:821.
2. Hirashima M, et al. 2009. Blood 93:1253.
3. Matsuyoshi N, et al. 1997. Proc. Assoc. Am. Physicians 109:362.
4. Matsumura K, et al. 2003. Blood 101:1367.
5. Hirashima M, et al. 2009. Blood 101:2261.
6. Gotsch U, et al. 1997. J. Cell Sci. 110:583.
7. Kataoka H, et al. 1997. Dev. Growth Differ. 39:729.
- Gene ID
- 12562 View all products for this Gene ID
- View information about CD144 on UniProt.org
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