- MH3-2 (See other available formats)
- Regulatory Status
- Other Names
- T cell receptor V beta 5
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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Vβ5 T cell receptor (TCR Vβ5) is a variant of the TCR β chain which is heterodimerized with TCR α chain and expressed on a subset of αβ+ T cells. TCR α/β recognizes peptides presented by the MHC molecules and initiates T cell mediated immune responses. Patients with multiple sclerosis present an expansion of Vβ5.2+/5.3+ autoreactive T cells.Product Details
- Human, Cross-Reactivity: Macaque
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_10643416 (BioLegend Cat. No. 349301)
- Immunoglobulin superfamily, associates with TCR Vα chain and CD3 complex
- Subset of TCR αβ+ T cells
- Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune response
- MHC-peptide complex
- Cell Type
- T cells
- Biology Area
- Immunology, Adaptive Immunity
- Molecular Family
- Antigen References
1. Kuchroo VK, et al. 2002. Annu. Rev. Immunol. 20:101.
2. Venturi V, et al. 2008. Nat. Rev. Immunol. 8:231.
3. Matsumoto Y, et al. 2003. J. Immunol. 170:4846.
4. Killestein J, et al. 2002. Ann. Neurol. 51:467.
- Gene ID
- 6957 View all products for this Gene ID
- View information about TCR V beta5 on UniProt.org
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