- P1F6 (See other available formats)
- Regulatory Status
- Other Names
- ITGAV, MSK8, VNRA, VTNR
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor α chain, or integrin αV. It forms heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling and mediates bone absorption and angiogenesis.Product Details
- Human, Rat, Cross-Reactivity: Hamster
- Antibody Type
- Host Species
- The P1F6 monoclonal antibody was generated against human small cell lung carcinoma cells (UCLA P3).
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.50 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
P1F6, reacts with the avß5 integrin complex. This antibody does not cross react with any other av containing integrin and completely inhibits avß5 dependent binding to vitronectin coated surfaces.
AB_2571949 (BioLegend Cat. No. 920004)
- Two disulfide-linked subunits of 125 kD and 24 kD.
Endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.
- As an adhesion molecule, it plays important roles in leukocytes homing and rolling as well as mediates bone absorption and angiogenesis.
- Forms heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8.
- Cell Type
- Endothelial cells, Fibroblasts, Macrophages, Mesenchymal Stem Cells, Osteoclasts, Platelets
- Biology Area
- Cell Adhesion, Cell Biology, Costimulatory Molecules, Neuroscience, Stem Cells, Synaptic Biology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Burvenich I, et al. 2008. Mol. Cancer Ther. 7(12):3771.
2. Lee P, et al. 2014. J. Biol. Chem. 289(3):1467.
3. Su G, et al. 2007. Am. J. Respir. Cell Mol. Biol. 36(3):377.
4. Wayner EA, et al. 2007. Methods in Enzymology 426:117.
5. Weinacker A, et al. 1994. J. Biol. Chem. 269(9):6940.
- Gene ID
- 3685 View all products for this Gene ID
- View information about CD51 on UniProt.org
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