- L168B11 (See other available formats)
- Regulatory Status
- Other Names
- Colony Stimulating Factor 1 (Macrophage), Macrophage Colony-Stimulating Factor, Lanimostim, CSF1, CSF-1, MCSF
- Mouse IgG3, κ
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- Product Citations
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M-CSF is a cytokine that controls the development, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer. M-CSF is released by fibroblasts, breast cancer cell lines, alveolar macrophages, stromal bone marrow cells, endothelial cells, and mesenchymal cells. It binds CD14+ monocytes and promotes the survival/proliferation of human peripheral blood monocytes. In addition, M-CSF enhances inducible monocyte functions, including phagocytic activity, microbial killing, cytotoxicity against tumor cells as well as synthesis of inflammatory cytokines such as IL-1β, TNF-α, and IFN-γ in monocytes. M-CSF induces RANKL production in mature human osteoclasts; consequently, M-CSF is a potent stimulator of mature osteoclast resorbing activity. Also, M-CSF induces monocyte-derived VEGF in human tumors. High levels of M-CSF, mononuclear phagocytes, and VEGF are associated with poor prognosis in patients with cancer.Product Details
- Antibody Type
- Host Species
- Human M-CSF
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IP - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunoprecipitation. For immunoprecipitation, the suggested use of this reagent is 2-10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2564049 (BioLegend Cat. No. 661602)
- Three isoforms with 256-554 amino acids, predicted molecular weight of approximately 30-70 kD.
Cell membrane as a single-pass membrane protein. Processed macrophage colony-stimulating factor 1 is secreted into the extracellular space.
- Controls the production, differentiation, and function of macrophages.
- Disulfide-linked homodimer or heterodimer that interacts with CSF1R.
- M-CSFR or CSF1R (CD115).
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Immunology
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
1. Kawasaki ES, et al. 1985. Science 230:291.
2. Wei S, et al. 2010. J. Leukoc. Biol. 88:495.
3. Hodge JM, et al. 2011. PloS One 6:e21462.
4. Morandi A, et al. 2011. PloS One 6:e27450.
5. Erblich B, et al. 2011. PloS One 6:e26317.
6. MacDonald KP, et al. 2010. Blood 116:3955.
- Gene ID
- 1435 View all products for this Gene ID
- View information about M-CSF on UniProt.org
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