- 22-19-12 (See other available formats)
- Regulatory Status
- Other Names
- SRPSOX, CXCXLG16, SR-PSOX
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CXCL16, a 27 kD chemokine, exists in membrane-bound and soluble forms. Unlike classic chemokines, CXCL16 possesses a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail with a tyrosine phosphorylation domain, allowing it to be expressed on the cell surface. Structurally, it is similar to fractalkine. It is expressed by dendritic cells, monocytes, and T cells. T cells can also migrate in response to CXCL16.
CXCL16 can also act as a scavenger receptor on macrophages. Its receptor is CXCR6/Bonzo. It can bind oxidized LDL and thus may play an important role in atherosclerosis. Recent studies have shown a role for CXCL16 in kidney fibrosis and in autoimmunity. CXCL16 is also a co-receptor for HIV.
- Antibody Type
- Host Species
- Purified human SR-PSOX-Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats of this clone) include: in vitro blocking of chemotactic activity of CXCR6 expressing cells1. Clone 22-19-12 recognizes the chemokine domain of CXCL16 and has been shown to inhibit chemotactic activity to CXCR6-expressing cells by soluble CXCL16.1
(PubMed link indicates BioLegend citation)
- Shimaoka T, et al. 2003. J. Immunol. 171:1647. (FC, Block)
AB_2562794 (BioLegend Cat. No. 360802)
- ~27 kD, exists as a membrane bound and soluble forms
- Produced by dendritic cells and T cells
- Binds to oxidized LDL and may play an important role in atherosclerosis
- Interacts with CXCR6/Bonzo
- Cell Type
- Dendritic cells, T cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Antigen References
1. Matloubian M, et al. 2000. Nat. Immunol. 1:298.
2. Wilbanks A, et al. 2001. J. Immunol. 166:5145.
3. Shimaoka T, et al. 2003. J. Immuniol. 171:1647.
4. Chandrasekar B, et al. 2004. J. Biol. Chem. 179:3188.
5. Shimaoka T, et al. 2004. J. Leukoc. Biol. 75:267.
- Gene ID
- 58191 View all products for this Gene ID
- View information about CXCL16 on UniProt.org
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