- A18087E (See other available formats)
- Regulatory Status
- Other Names
- T cell immunoglobulin and mucin domain containing protein 3, hepatitis virus cellular receptor 2, CD366
- Mouse IgG1, k
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- Product Citations
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CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.Product Details
- Antibody Type
- Host Species
- Recombinant human Tim-3
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2892442 (BioLegend Cat. No. 364802)
- Transmembrane protein containing immunoglobulin domain and mucin-like domain; can exist as a soluble form lacking mucin and transmembrane domains
Activated T cells, preferentially on Th1 cells, monocytes, dendritic cells
- CD366 plays a role in regulating macrophage activation, checkpoint inhibitor, T cell apoptosis and immune tolerance
- Galectin-9 and PtdSer
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
- Hafler DA and Kuchroo V. 2008. J Exp Med. 205:2699.
- Zhu C, et al. 2005. Nat Immunol. 6:1245.
- Wang F, et al. 2009. Immunobiology. 214:342.
- Gene ID
- 84868 View all products for this Gene ID
- View information about CD366 on UniProt.org
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