Purified anti-human CD352 (NTB-A) Antibody

Pricing & Availability
Clone
W19035D (See other available formats)
Other Names
SLAMF6, LY108, TCOM, SF2000, NTBA
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W19035D_PURE_CD352_Antibody_1_032221
Human peripheral blood lymphocytes were surface stained with purified CD352 (NTB-A) (clone W19035D) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram).
  • W19035D_PURE_CD352_Antibody_1_032221
    Human peripheral blood lymphocytes were surface stained with purified CD352 (NTB-A) (clone W19035D) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram).
Cat # Size Price Quantity Avail. Save
332302 100 µg $100
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Description

NTBA (NK-, T-, and B-cell Antigen) is a 60 kD type I transmembrane glycoprotein. It is a member of Ig superfamily belonging to CD2/CD150 subfamily, also known as SLAMF6 (SLAM family member 6), LY108, TCOM, or SF2000. This antigen is expressed on NK cells, T cells (upregulated upon activation), and B cells. NTBA is its own ligand. The homophilic interaction of NTBA is involved in the induction of NK cytotoxicity, CD28 independent T cell costimulation, triggering Th1 cytokines production, and regulation of B cell tolerance. It may play a role in the regulation of autoimmune diseases.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Extracellular domain of hIL-21R
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
Type I transmembrane tyrosine-phosphorylated glycoprotein, CD2/CD150 subfamily, 60 kD
Distribution

NK cells, T cells, B cells

Function
CD28 independent T cell costimulation, induction of NK cell cytotoxicity, regulation of B cell tolerance
Ligand/Receptor
NTBA
Antigen References

1. Yigit B, et al. 2019. Cancer Immunol. Res. 10.1158/2326-6066
2. Wu N, et al. 2016. Nature Immunol. 17, 387-396
3. Radomir L, et al. 2017. J. Immunol. 199(8) 2745-2757

 

Gene ID
114836 View all products for this Gene ID
UniProt
View information about CD352 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03/22/2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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