- SHM38 (See other available formats)
- Regulatory Status
- Other Names
- CD213a2, IL-13RA2, IL-13R, IL13BP, CT19
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD213a2, also known as IL-13Rα2, is a type I transmembrane protein and member of the hematopoietin family. IL13Ra2 is the high affinity receptor for IL-13, but it possibly acts as a decoy receptor to antagonize IL-13Rα1/IL-4Ra-mediated IL-13 biological functions. IL13Rα2 is expressed by fibroblasts, smooth muscle cells, keratinocytes and activated B cells. However, its presence on the cell surface is highly regulated. CD213a2 is also expressed in various types of cancer which makes it an attractive therapeutic target.Product Details
- Human, Rhesus
- Antibody Type
- Host Species
- Melanoma cell line A375
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Takenouchi M, et al. 2011. Clin. Cancer Res. 17:2819. (FC)
AB_2561520 (BioLegend Cat. No. 354401)
AB_2561521 (BioLegend Cat. No. 354402)
- Member of the hematopoietin family, type I transmembrane protein, contains 1 fibronectin type III domain
Fibroblasts, smooth muscle cells, keratinocytes, activated B cells
- Possible decoy receptor, antagonist of CD213a1, internalization of IL-13
- Cell Type
- B cells, Fibroblasts
- Biology Area
- Cell Biology, Immunology, Transcription Factors
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1. Mitchell J, et al. 2010. Curr. Opin. Investig Drugs. 11:527.
2. Strober W, et al. 2009. Curr. Mol. Med. 9:740.
3. Tabata Y, et al. 2007. Curr. Allergy Asthma Rep. 7:338.
- Gene ID
- 3598 View all products for this Gene ID
- View information about CD213a2 on UniProt.org
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