- 33.1 (Ab33) (See other available formats)
- Regulatory Status
- Other Names
- Tie2, TEK
- Mouse IgG1 κ
- Ave. Rating
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- Product Citations
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CD202b is a 145 kD type I transmembrane protein, also known as Tie2 or TEK. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.Product Details
- Antibody Type
- Host Species
- Recombinant extracellular domain of human Tie2
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP, WB, IHC-F , ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications include: immunoprecipitation, Wstern blot, immunohistochemical staining of frozen tissue sections and ELISA
(PubMed link indicates BioLegend citation)
- Peters KG, et al. 1998. Br. J. Cancer. 77:51.
- Wong AL, et al. 1997. Circ. Res. 81:567.
- Lin P, et al. 1998. P. Natl. Acad. Sci. USA 95:8829.
AB_1134251 (BioLegend Cat. No. 334202)
- 145 kD type I transmembrane protein, receptor tyrosine kinase (RTK) family
Endothelial cells, subsets of hematopoietic stem cells and and a subset of monocytes
- Angiogenesis, hemotopoiesis, monocytes chemotaxis
- Angiopoietin-1 (Ang-1), Ang-2, and Ang-4
- Cell Type
- Endothelial cells, Hematopoietic stem and progenitors, Monocytes
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1.De Palma M, et al. 2005. Cancer Cell. 8:211
2.Shaw JP, et al. 2004. Blood Cells Mol. Dis. 32:168
3. Hsu HC, et al. 2000. Blood. 96:3757
4. Arai F, et al. 2004. Cell. 118:149
- Gene ID
- 7010 View all products for this Gene ID
- View information about CD202b on UniProt.org
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