- S-HCL-3 (See other available formats)
- Regulatory Status
- Other Names
- Integrin αX subunit, CR4, p150, ITGAX
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.Product Details
- Antibody Type
- Host Species
- Spleen cells from patient diagnosed with hairy cell leukemia.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F, IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemistry on frozen tissue sections1,2,3,4 and immunoprecipitation1.
(PubMed link indicates BioLegend citation)
- Schwarting R, et al. 1985. Blood 65:974.
- Knowles DM, et al. 1990. Am. J. Pathol. 136:29.
- Vandenabeele S, et al. 2001. Blood 97:1733.
- Shaw JL, et al. 2011. J. Reprod. Immunol. 89:84.
AB_2616755 (BioLegend Cat. No. 371502)
- Integrin, type I transmembrane glycoprotein, associates with integrin ß2 (CD18), 145-150 kD.
Myeloid, dendritic cells, NK cells, B cells and T cell subsets.
- Adhesion and CTL killing.
- Interacts with fibrinogen, CD54, and iC3b.
- CD54, fibrinogen, iC3b, ICAM-1, ICAM-4
- Cell Type
- B cells, Dendritic cells, NK cells, T cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Petty HR, Todd RF 3rd. 1996. Immunol. Today 17:209.
2. Springer T. 1994. Cell 76:301.
3. Ihanus E, et al. 2007. Blood 109:802-10.
- Gene ID
- 3687 View all products for this Gene ID
- View information about CD11c on UniProt.org
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