Purified anti-Galectin-9 Antibody

Pricing & Availability
Clone
9S2-1 (See other available formats)
Regulatory Status
RUO
Other Names
Lgals9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, Ecalectin
Isotype
Mouse IgG1, κ
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Product Citations
publications
9S2-1_Purified_Galectin-9_Antibody_WB_031115
Western blot analysis of mouse thymus (lane 1), MEF (lane 2), Jurkat (lane 3), and Raji (lane 4) cells using anti-Galectin-9 antibody (Clone 9S2-1). β-actin (poly6221) was used as loading control.
  • 9S2-1_Purified_Galectin-9_Antibody_WB_031115
    Western blot analysis of mouse thymus (lane 1), MEF (lane 2), Jurkat (lane 3), and Raji (lane 4) cells using anti-Galectin-9 antibody (Clone 9S2-1). β-actin (poly6221) was used as loading control.
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650701 25 µg $105.00
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650702 100 µg $225.00
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Description

Galectin-9 is a mammalian lectin with a molecular weight around 40 kD. It is a member of the β-galactoside-binding family. With two conserved carbohydrate recognition domains (CRDs), galectin-9 binds small β-galactosides as well as complex glycoconjugates.  HAVCR2/TIM3 has been reported as one of its ligands. Galectin-9 may be retained intracellularly or transported to the cell surface where it can be cleaved to generate a soluble form. Galectin-9 is expressed by lymphocytes, dendritic cells, granulocytes, eosinophils, astrocytes, endothelial cells, fibroblasts, and thymus epithelial cells. It can be induced by cytokines in various cell types and is involved in cell aggregation, adhesion, chemotaxis, and apoptosis; galectin-9 induces regulatory T cells and suppresses Th1 and Th17 responses.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human Galectin-9 (S-type)
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, 0.09% NaN3.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1 µg per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes
Does not cross react with mouse.
Application References

(PubMed link indicates BioLegend citation)
  1. Pielage JF, et al. 2007. Int. J. Biochem. Cell. Biol. 39:1886. (WB)
RRID
AB_10900999 (BioLegend Cat. No. 650701)
AB_10897952 (BioLegend Cat. No. 650702)

Antigen Details

Structure
355 amino acids; 40 kD
Distribution
Lymphocytes, dendritic cells, neutrophils, eosinophils, astrocytes, endothelial cells, fibroblasts, thymus stromal/epithelial cells.
Function
Cell aggregation, adhesion, chemotaxis, apoptosis, suppression of Th1 and Th17 responses, and induction of regulatory T cells.
Ligand/Receptor
HAVCR2/TIM3
Cell Type
Lymphocytes, Dendritic cells, Neutrophils, Eosinophils, Astrocytes, Endothelial cells, Fibroblasts, Epithelial cells
Biology Area
Cell Adhesion, Cell Biology, Immunology
Antigen References

1. Seki M, et al. 2008. Clin. Immunol. 127:78.
2. Tsubo IY, et al. 2007. Clin. Immunol. 124:221.
3. Zhu C, et al. 2005. Nat. Immunol. 6:1245.
4. Dunphy JL, et al. 2002. J. Biol. Chem. 277:14916.

Gene ID
3965 View all products for this Gene ID
UniProt
View information about Galectin-9 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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