- 11A5C44 (See other available formats)
- Regulatory Status
- Other Names
- Fibroblast growth factor 1 (FGF-1), Acidic fibroblast growth factor (aFGF), FGF-acidic, Endothelial cell growth factor (ECGF), Heparin-binding growth factor 1 (HBGF-1), FGF1, HBGF1
- Mouse IgG2b, λ
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- Product Citations
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FGF-1, one of the most studied members of the fibroblast growth factor family, is a powerful mitogen exhibiting strong action on many different cell types. FGF-1 activity can be mediated not only by autocrine/paracrine pathways, but also by an intracrine pathway. FGF-1 lacks a secretion signal peptide and is exported through a non-classical pathway. Endogenous FGF-1 is found in the nucleus of most cell types. Nuclear localization is required for FGF-1 mitogenic activity. FGF-1 promotes tumor development by promoting cancer cell proliferation and survival. Increased FGF-1 expression in early stages of many different cancers have been reported. MCF-7 breast cancer cell lines that overexpress FGF-1 can form vascularized, metastatic tumors when injected into ovariectomized or tamoxifen-treated nude mice. FGF-1 also induces angiogenesis in vitro and in vivo. Thus, FGF-1 is an attractive candidate for cancer immunotargeting. FGF-1 is also involved in neuronal cell differentiation and survival. FGF-1 is highly expressed in motor neurons. In response to damage, motor neurons can release FGF-1, which results in astrocyte activation. Under oxidative stress, astrocytes can also release FGF-1, which stimulates ApoE/HDL generation in an autocrine manner for protection of the brain against oxidative stress. The involvement of FGF-1 in inflammation, cardioprotection, wound healing, adipocyte remodeling, and restenosis have also been reported.Product Details
- Antibody Type
- Host Species
- Parital human human FGF-1 recombinant protein (16-155 a.a.) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2565906 (BioLegend Cat. No. 678602)
- The 140 amino acid recombinant protein has a predicted molecular mass of approximately 16 kD. Growth factor.
- Secreted. FGF-1 is widely expressed in developing and adult tissues.
- FGF-1 plays an important role in many biological processes, including cell proliferation, inflammation, and angiogenesis. FGF-1 has a low stability and a very short half-life in vivo. Binding to heparin increases the stability of FGF-1 and is also important for the formation of active FGF-acidic/FGFR complex.
- Intracellular FGF-1 can interact directly with CK2, FIBP, mortalin, and the ribosome-binding protein p34/leucine-rich repeat containing 59 (LRRC59).
- FGF-1 can signal through all known cell-surface FGFR isoforms (FGFR1b, 1c, 2b, 2c, 3b, 3c, and 4). FGF-1 also binds to heparin and heparin sulfate proteoglycans on the cell surface.
- Biology Area
- Angiogenesis, Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, Growth Factors, Cytokines/Chemokines
- Antigen References
1. Presta M, et al. 2005. Cytokine Growth Factor Rev. 2:159.
2. Zakrzewska M, et al. 2008. Crit. Rev. Clin. Lab. Sci. 45:91.
3. Zhang L, et al. 1997. Oncogene. 15:2093.
4. Lin YZ, et al. 1996. J. Biol. Chem. 271:5305.
5. Culajay JF, et al. 2000. Biochemistry 39:7153.
6. Cassina P, et al. 2005. J. Neurochem. 93:38.
7. Pehar M, et al. 2005. Neurodegener. Dis. 2:139.
8. Jonker JW, et al. 2012. Nature 485:391.
9. Compagni A, et al. 2000. Cancer Res. 60:7163.
- Gene ID
- 2246 View all products for this Gene ID
- View information about FGF-1-acidic on UniProt.org
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