- 14D2C43 (See other available formats)
- Regulatory Status
- Other Names
- ARG1, Liver Arginase, Type 1 Arginase, Arginase-1, Liver-Type Arginase
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Arginase I, also known as ARG1, is a 34.7kD protein expressed by neutrophils and myeloid-derived suppressor cells (MDSCs). There are two isoforms that are differentiated based on their tissue distribution and subcellular localization. Arginase I converts L-arginine into L-ornithine and urea; it is the final enzyme in the urea cycle. While mostly found in the liver, it can also be expressed in cells lacking a comprehensive urea cycle. Also, it contributes to vasodilation and vascular function. Arginase I is also reported to be involved in MDSC mediated suppression of T cell proliferation. Arginase I has been implicated in hyperargininemia (decreased function of arginase I) and Q fever.Product Details
- Antibody Type
- Host Species
- Full length recombinant protein expressed in E.coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2814330 (BioLegend Cat. No. 369707)
AB_2814331 (BioLegend Cat. No. 369708)
- Belongs to the ureohydrolase family and has a molecular mass of 34.7 kD.
Neutrophils and myeloid-derived suppressor cells (MDSC).
- Converts L-arginine into L-ornithine and urea.
- Cell Type
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
1. Munder M, et al. 2005. Blood 105:2549.
2. Luckner-Minden C, et al. 2010. JLB. 87:1125.
3. Holowatz L, et al. 2006. Journal of Physiology 574:573.
4. Sin YY, et al. 2013. PLoS One 8:11.
5. Benoit M, et al. 2008. Eur. J. Immunol. 4:1065.
- Gene ID
- 383 View all products for this Gene ID
- View information about Arginase I on UniProt.org
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