- W17037B (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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IL-31, mainly produced by activated CD4+ T cells, is a helical cytokine belonging to the gp130/IL-6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Transgenic mice overexpressing IL-31 developed severe dermatitis, indicating that IL-31 is involved in skin immunity.Product Details
- Antibody Type
- Host Species
- Recombinant mouse IL-31
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2876573 (BioLegend Cat. No. 160703)
AB_2876573 (BioLegend Cat. No. 160704)
- Member of IL-6 family of cytokines
Subset of CD4 T cells
- Cell Type
- Lymphocytes, T cells, Th2, Thymocytes
- Biology Area
- Adaptive Immunity, Immunology, Innate Immunity
- Molecular Family
- Antigen References
- McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42.
- Arai I, et al. 2013. Exp. Dermatol. 22:669.
- Dai X, et al. 2013. PLoS One. 8:e67666.
- Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446.
- Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232.
- Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5
- Gene ID
- 76399 View all products for this Gene ID
- View information about IL-31 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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