PE anti-mouse CD18 Antibody

Pricing & Availability
M18/2 (See other available formats)
Regulatory Status
Other Names
integrin β2, β2 integrin, ITGB2
Rat IgG2a, κ
Ave. Rating
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Product Citations
C57BL/6 splenocytes stained with M18/2 PE
  • M18/2
    C57BL/6 splenocytes stained with M18/2 PE
See PE spectral data
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101407 50 µg $70
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101408 200 µg $230
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CD18 is a 95 kD protein, also known as integrin β2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
Mouse CTL glycoprotein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, Western blotting1, in vitro and in vivo blocking of tumor cells metastasis or stimulation of cell-adhesion2-6, and immunohistochemical staining7 of acetone-fixed frozen sections and formalin-fixed paraffin-embedded sections. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 101417-101422).

Application References

(PubMed link indicates BioLegend citation)
  1. Sanchez-Madrid, et al. 1983. J. Exp. Med. 158:586. (IP, WB)
  2. Zahalka MA, et al. 1993. J. Immunol. 150:4466. (IP, Block, Stim)
  3. Zahalka MA, et al. 1994. Int. Immunol. 6:917. (Block, Stim)
  4. Ishida Y, et al. 1994. Cell. Immunol. 155:414. (Block, Stim)
  5. Isobe M, et al. 1992. Science 255:1125. (Block, Stim)
  6. Driessens MHE, et al. 1996. J. Leukoc. Biol. 60:758. (Block, Stim)
  7. Barlow SC, et al. 2004. Amer. J. Pathol. 165:1849. (IHC)
Product Citations
  1. Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed
  2. Horiguchi H, et al. 2019. Genes Dev. 33:1641. PubMed
  3. Hasenberg M, et al. 2011. PLoS One. 6:e17314. PubMed
  4. Simonetti G, et al. 2013. J Exp Med. 210:2887. PubMed
  5. Yang M, et al. 2015. J Appl Physiol. 119: 77 - 82. PubMed
  6. Yang M, et al. 2015. J Appl Physiol. 119: 219-222. PubMed
  7. Richardson ET, et al. 2015. PLoS One. 10: 1371. PubMed
  8. Silva N, et al. 2016. J Immunol. 196: 2591 - 2601. PubMed
  9. Break T, et al. 2016. Infect Immun . 84(12):3302-3312. PubMed
  10. Kumar A, et al. 2017. J Neuroinflammation . 10.1186/s12974-017-0819-4. PubMed
  11. Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed
  12. Ross EC, et al. 2021. Cell Mol Life Sci. 78:5197. PubMed
AB_312816 (BioLegend Cat. No. 101407)
AB_312817 (BioLegend Cat. No. 101408)

Antigen Details

Integrin family, associates with CD11a, CD11b, CD11c, 95 kD

All leukocytes

ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, fibrinogen
Cell Type
Leukocytes, Tregs
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Anderson DC, et al. 1987. Annu. Rev. Med. 38:175.
3. Wilson RW, et al. 1993. J. Immunol. 151:1571.

Gene ID
16414 View all products for this Gene ID
View information about CD18 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 03/07/2013

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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