- MRP 1H9 (See other available formats)
- Regulatory Status
- Other Names
- S100A9, Migration inhibitory factor-related proteins-14, Calgranulin-B, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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MRP-14, also known as S100A9, belongs to the S100 family of proteins containing 2-EF-hand calcium-binding motifs. It forms non-covalently associated complexes with another S100 family member, MRP-8. MRP14 is expressed in neutrophils and monocytes; it also has been found in ileal tissue eosinophils. The S100A8/A9 complex has been shown to play a role during calcium-dependent activation as well as have antibacterial, antifungal, immunomodulating, and anti-proliferative effects. It also functions as a chemoattractant factor for neutrophils and has been considered an endogenous activator of Toll-like receptor 4. S100A9 has been identified as a marker for CD14(+) HLA-DR(-/low) MDSCs.Product Details
- Antibody Type
- Host Species
- Recombinant human MRP-14
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
This clone has been published as 1H9.
Additional reported applications (for the relevant formats) include: Western blotting1 and immunohistochemical staining with paraffin-embedded tissue sections1,2.
(PubMed link indicates BioLegend citation)
- Robinson MJ, et al. 2002. J. Biol. Chem. 277:3658. (WB, IHC)
- Croce K, et al. 2009. Circulation 120:427. (IHC)
- Andricovich J, et al. 2016. J. Clin. Invest. 126:905. (ICFC) Pubmed
- Product Citations
AB_2564007 (BioLegend Cat. No. 350705)
AB_2564008 (BioLegend Cat. No. 350706)
- Belongs to S100 family of proteins containing 2-EF-hand calcium -binding motifs, forms non-covalently associated complexes with another S100 family member MRP-8
MDSCs, neutrophils, monocyte, and ileal tissue eosinophils
- Calcium-dependent activation, immunomodulating and antiproliferative, endogenous activator of Toll-like receptor 4
- Cell Type
- Neutrophils, Monocytes, Eosinophils
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Adhesion Molecules
- Antigen References
1. Loser K, et al. 2010. Nat. Med. 16:713.
2. Cheng P, et al. 2008. J. Exp. Med. 205:2235.
3. Leukert N, et al.2006. J. Mol. Biol. 359:961.
4. Lagasse E, et al. 1988. Mol. Cell. Biol. 8:2402.
5. Zhao F, et al. 2012. Immunology. 136:176.
- Gene ID
- 6280 View all products for this Gene ID
- View information about MRP-14 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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