- 4BG1 (See other available formats)
- Regulatory Status
- Other Names
- Interleukin 21
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Rohman M, et al. 2007. FEBS Lett. 581:4001.
- Onoda T, et al. 2007. Int. Immunol. 19:1191.
- Product Citations
AB_2125257 (BioLegend Cat. No. 516703)
AB_2125256 (BioLegend Cat. No. 516704)
- Cell Sources
- NK-T cells and T cells
- Cell Targets
- cytotoxic T cells (CTL) and Natural Killer (NK) cells, that can destroy malignant or infected cells
- Cell Type
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Antigen References
1. Nurieva R. 2007. Nature 448:416.
2. Parrish-Novak J, et al. 2002. J. Leukocyte Biol. 72:856.
3. Dumoutier L, et al. 2000. Proc. Natl. Acad. Sci. USA 97:10144.
4. Asao H, et al. 2001. J. Immunol. 167:1.
5. Parrish-Novak J, et al. 2000. Nature 408:57.
- Gene ID
- 59067 View all products for this Gene ID
- View information about IL-21 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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