PE anti-human GARP (LRRC32) Antibody

Pricing & Availability
7B11 (See other available formats)
Regulatory Status
Other Names
Garpin, Glycoprotein A repetitions predominant
Mouse IgG2b, κ
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Product Citations
  • 7B11_PE_1_072611
  • 7B11_PE_2_072611
    Human peripheral blood mononuclear cells were stimulated with CD3 (UCHT1), CD28 (CD28.2), and recombinant human IL-2 for 24 hours; and then surface stained with CD4 FITC, GARP (7B11) PE (top) or mouse IgG2b, κ PE isotype control (middle), followed by intracellular staining with FOXP3 Alexa Fluor® 647; or surface stained with CD4 PerCP, GARP (clone 7B11) PE and LAP/TGF-β1 APC (bottom). The data was analyzed on CD4-positive cells.
  • 7B11_PE_3_072611
See PE spectral data
Cat # Size Price Quantity Check Availability Save
352503 25 tests $130.00
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352504 100 tests $300.00
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Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs (CD4+, CD25+, FoxP3+ cells) and serves as a receptor for latent TGF-β. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1, an autosomal recessive disease characterized by profound congenital sensorineural deafness, vestibular dysfunction, and progressive visual loss. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-β or to capture TGF-β from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
LRRC32-DNA vaccination
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Imura Y, et al. 2020. JCI Insight. :5. PubMed
AB_10896792 (BioLegend Cat. No. 352503)
AB_10900640 (BioLegend Cat. No. 352504)

Antigen Details

80 kD transmembrane GARP glycoprotein with an extracellular region containing 20 leucine-rich repeats

Activated Tregs, megakaryocytes, platelets

LAP (TGF-β1)
Cell Type
Megakaryocytes, Platelets, Tregs
Biology Area
Cell Biology, Immunology, Signal Transduction
Antigen References

1. Ollendorff V, et al. 1994. Cell. Growth Differ. 5:213.
2. Stockis J, et al. 2009. Eur. J. Immunol. 39:3315.
3. Wang R, et al. 2009. P. Natl. Acad. Sci. USA 106:13439.
4. Tran DQ, et al. 2009. P. Natl. Acad. Sci. USA 106:13445.

Gene ID
2615 View all products for this Gene ID
View information about GARP on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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