- A16085H (See other available formats)
- Regulatory Status
- Other Names
- VEGFR2, KDR
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.Product Details
- Antibody Type
- Host Species
- Recombinant Human VEGFR2-Fc Chimera
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
This clone does not cross-react with mouse endothelial cells.
AB_2734448 (BioLegend Cat. No. 393003)
AB_2734449 (BioLegend Cat. No. 393004)
- Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1/PDGF receptor family
Endothelial cells, embryonic tissues
- VEGFR2 regulates angiogenesis as well as vascular development and permeability.
- VEGF-A, VEGF-C, and VEGF-D splice isoforms
- Cell Type
- Endothelial cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
- DiSalvo J, et al. 1995. J Biol Chem. 270:7717.
- McColl BK, et al. 2003. J Exp Med. 198:863.
- Albuquerque RJ, et al. 2009. Nat Med. 15:1023.
- Guangqi E, et al. 2012. J Biol Chem. 287:3029.
- Koch S, and Claesson-Welsh. 2012. Cold Spring Harb Perspect Med. 2:a006502.
- Munaut C, et al. 2012. Plos One. 7:e33475.
- Wehland M, et al. 2013. Int J Mol Sci. 14:9338.
- Gene ID
- 3791 View all products for this Gene ID
- View information about CD309 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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