FITC anti-mouse CD26 (DPP-4) Antibody

Pricing & Availability
Clone
H194-112 (See other available formats)
Regulatory Status
RUO
Other Names
Dipeptidyl peptidase 4, THAM
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
H194-112_FITC_092910
Balb/c splenocytes stained with anti-mouse CD26 (H194-112) FITC and CD3 (17A2) Alexa Fluor® 647
  • H194-112_FITC_092910
    Balb/c splenocytes stained with anti-mouse CD26 (H194-112) FITC and CD3 (17A2) Alexa Fluor® 647
See FITC spectral data
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137805 25 µg $60.00
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137806 100 µg $135.00
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Description

CD26, also known as DPP IV or THAM, is a 220 kD type II transmembrane homodimer. It consists of an α/β hydrolase domain and an eight-blade beta-propeller domain.  After proteolysis of the membrane-bound CD26, a soluble form of DPP IV is released. CD26 is expressed on thymocytes (development dependent), T cells, B cells, NK cells, and macrophages. It is involved in T cell costimulation, endothelial cell migration and proteolysis processes.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
BALB/c thymocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications include: in vitro activation of thymocytes1, immunoprecipitation from cell lysates and cell-free supernatants1,2 and immunohistochemical staining of frozen tissue sections1.

Application References

(PubMed link indicates BioLegend citation)
  1. Naquet P, et al. 1988. J. Immunol. 141:4101.
  2. Vivier I, et al. 1991. J. Immunol. 147:447.
  3. Sen A, et al. 2012. PNAS PubMed
  4. Coleman CM, et al. 2014. J Gen Virol. 95:408. PubMed
Product Citations
  1. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  2. Deniset JF et al. 2019. Immunity. 51(1):131-140 . PubMed
  3. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  4. Giles DA, et al. 2018. J Clin Invest. 128:5322. PubMed
  5. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
RRID
AB_10662380 (BioLegend Cat. No. 137805)
AB_10663402 (BioLegend Cat. No. 137806)

Antigen Details

Structure
Homodimer, each monomer is a single chain type II transmembranal molecule of 110 kD that consists of two domains; soluble form is released after proteolysis of the membrane form
Distribution

Mature thymocytes, activated T cells, B cells, NK cells, macrophages

Function
T cell costimulation, endothelial cell migration, proteolysis
Interaction
CAV1, IGF2R, PTPRC, BCL10, CARD1, IKBKB
Ligand/Receptor
ADA, collagen
Cell Type
B cells, Macrophages, NK cells, T cells, Thymocytes
Biology Area
Immunology, Costimulatory Molecules
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Cooper KG, et al. 2009. Infect. Immun. 77:2447.
2. Eltzschig HK, et al. 2006. Blood 108:1602.
3. Peranteau WH, et al. 2006. Blood 108:4268.

Gene ID
13482 View all products for this Gene ID
UniProt
View information about CD26 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 11/15/2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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