- 19F2 (See other available formats)
- Regulatory Status
- Other Names
- BCM, TNFRSF17
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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CD269, also known as B cell maturation antigen (BCMA), is a 27 kD, single pass transmembrane protein with one TNFR-Cys repeat on its extracellular domain. CD269 is a B cell maturation factor, essential for the long-term survival of plasma cells. It is expressed by plasmablasts, plasma cells, and germinal center B cells. The ligands of CD269 are BAFF and APRIL, and its cytoplasmic domain binds several of the TRAF family members.Product Details
- Antibody Type
- Host Species
- BCMA-mouse IgG Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
Red Laser (633 nm)
- Product Citations
AB_2686990 (BioLegend Cat. No. 357515)
AB_2686991 (BioLegend Cat. No. 357516)
- Single pass transmembrane protein, member of the TNFR superfamily, 1 TNFR-Cys domain, 27 kD
Plasmablasts, plasma cells, germinal center B cells
- B cell maturation factor, essential for survival of plasma cells
- Associates with several TRAF family members
- BAFF, APRIL
- Cell Type
- B cells, Plasma cells
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Coquery CM and Erickson LD. 2012. Crit. Rev. Immunol. 32:287.
2. Notas G, et al. 2012. J. Immunol. 189:4748.
3. Rickert RC, et al. 2011. Immunol. Rev. 244:115.
4. Mesin L, et al. 2011. J. Immunol. 187:2867.
- Gene ID
- 608 View all products for this Gene ID
- Specificity (DOES NOT SHOW ON TDS):
- Specificity Alt (DOES NOT SHOW ON TDS):
- View information about CD269 on UniProt.org
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