- P1H12 (See other available formats)
- Regulatory Status
- HCDM listed
- Other Names
- Muc-18, MCAM, Mel-CAM, S-endo
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD146 is a 118 kD integral transmembrane glycoprotein that is also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). It belongs to the immunoglobulin superfamily. CD146 is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified.Product Details
- Human, Cross-Reactivity: Mouse, Canine2, 5, Rabbit
- Antibody Type
- Host Species
- Cultured human umbilical cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats of this clone) include: Western blotting3 and IHC1,5.
(PubMed link indicates BioLegend citation)
- Solovey A, et al. 1997. N. Engl. J. Med. 337:1584. (FC, IHC)
- Lamerato-Kozicki AR, et al. 2006. Exp. Hematol. 34:870. (FC)
- Balint K, et al. 2005. J. Clin. Invest. 115:3166. (WB)
- Neskey DM, et al. 2008. J. Exp. Clin. Cancer Res. 27:61. (ELISA)
- Kamstock D, et al. 2006. Cancer Gene Therap. 13:306. (IHC)
- 118 kD integral glycoprotein, Ig superfamily
Melanoma cells, epithelial cells, endothelial cells, activated T cells, multipotent mesenchymal stromal cells
- Adhesion, monocytes transendothelial migration
- Cell Type
- Endothelial cells, Epithelial cells, Mesenchymal cells, Mesenchymal Stem Cells, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Pickl WF, et al. 1997. J. Immunol. 158:2107.
2. Weninger W, et al. 2000. J. Invest. Dermatol. 115:219.
3. Sorrentino A, et al. 2008. Exp. Hematol. 36:1035.
4. Bardin N, et al. 2009. Arterioscler. Thromb. Vasc. Biol. 29:746.
- Gene ID
- 4162 View all products for this Gene ID
- View information about CD146 on UniProt.org
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