APC anti-rat CD314 (NKG2D) Antibody

Pricing & Availability
Clone
11D5C9 (See other available formats)
Regulatory Status
RUO
Other Names
KLRK1, NKR2
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
11D5C9_APC_CD314_Antibody_112420
Lewis rat splenocytes were stained with CD161 PE and CD314 (NKG2D) (clone 11D5C9) APC (left) or mouse IgG1, κ APC isotype control (right).
  • 11D5C9_APC_CD314_Antibody_112420
    Lewis rat splenocytes were stained with CD161 PE and CD314 (NKG2D) (clone 11D5C9) APC (left) or mouse IgG1, κ APC isotype control (right).
See APC spectral data
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206305 25 µg $125.00
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206306 100 µg $280.00
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Description

NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells and a subset of T lymphocytes. NKG2D serves as a stimulatory receptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Rat NKG2D has been reported to induce the synthesis of IFN gamma and induce cytotoxicity in response to rat RAE1L and PRLT, RAE family members in rat. NKG2D is also involved in liver allograft rejection.

Product Details
Technical data sheet

Product Details

Reactivity
Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Rat NKG2D fused with human Fc
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2888696 (BioLegend Cat. No. 206305)
AB_2888696 (BioLegend Cat. No. 206306)

Antigen Details

Structure
A lectin-like type II transmembrane protein
Distribution

NK cells and a subset of T lymphocytes

Function
A stimulatory receptor to activate NK cells by association with DAP10 or DAP12 adaptor
Ligand/Receptor
RAE1L and PRLT
Cell Type
NK cells, NKT cells, T cells
Biology Area
Adaptive Immunity, Immunology
Molecular Family
CD Molecules, Immune Checkpoint Receptors, Innate Immune Signaling
Antigen References
  1. Obara H, et al. 2005. Am. J. Transplant. 5:2094-103.
  2. Raulet DH. 2003. Nat. Rev. Immunol. 3:781-790.
  3. Sun Z, et al. 2009. Hepatology. 49:587-597.
  4. Dissen E, et al. 1996. J. Exp. Med.183:2197-2207.
  5. Løvik G, et al. 1995. J. Immunol. Methods. 179:59-69.
  6. Ming Z, et al. 2010. Eur. J. Immunol. 40:1748-1757.
Gene ID
24934 View all products for this Gene ID
UniProt
View information about CD314 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/24/2020

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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