- TEK4 (See other available formats)
- Regulatory Status
- Other Names
- Tie-2, TEK
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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CD202b, also known as Tie-2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 also binds to Ang-4.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
- Sanchez-Martin L, et al. 2011. Blood 117:88. PubMed
- Product Citations
AB_10900267 (BioLegend Cat. No. 124009)
AB_10897106 (BioLegend Cat. No. 124010)
- The receptor tyrosine kinase (RTK) family
Endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes
- Cell Type
- Endothelial cells, Epithelial cells, T cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
2. Yano M, et al. 1997. Blood 89:431726.
3. Kolatsi-Joannou M, et al. 2001. Dev. Dyn. 222:1206.
- Gene ID
- 21687 View all products for this Gene ID
- View information about CD202b on UniProt.org
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