APC anti-human CD180 (RP105) Antibody

Pricing & Availability
MHR73-11 (See other available formats)
Regulatory Status
Other Names
CD180, Radio-protective 105-kD protein, RP105
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes were stained with CD180 (clone MHR73-11) APC (filled histogram) or mouse IgG1, κ isotype control APC (open histogram).
  • MHR73-11_APC_CD180_Antibody_100218
    Human peripheral blood lymphocytes were stained with CD180 (clone MHR73-11) APC (filled histogram) or mouse IgG1, κ isotype control APC (open histogram).
See APC spectral data
Cat # Size Price Quantity Avail. Save
312911 25 tests $125
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312912 100 tests $240
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CD180, also known as RP105, is a 105 kD member of the toll-like receptor (TLR) family and is expressed on most B cells, monocytes/macrophages and dendritic cells. The TLR family's structural characteristics are critically involved in protein-protein signaling interactions leading to the activation of the innate immune system. Additionally, MD-1, a secretory protein, associates with CD180 (RP105) at the cell surface and this complex, in conjunction with TLR4, recognizes bacterial LPS. The human CD180 (RP105) gene maps to 5q12. The MHR73-11 antibody is able to activate B cells and to protect against irradiation- or dexamethasone-induced apoptosis.

Product Details
Technical data sheet

Product Details

Human, Baboon, Cynomolgus, African Green, Rhesus
Antibody Type
Host Species
Human RP105 complexed with mouse MD-1
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: intracellular staining1, immunoprecipitation1, immunohistochemistry1 of acetone-fixed frozen tissue sections, B cell activation1, protection from apoptosis induced by radiation or dexamethasone, and induction of the costimulatory molecule CD80 (B7-1)1. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 312913 and 312914).

Application References

(PubMed link indicates BioLegend citation)
  1. Miura Y, et al. 1998. Blood 92:2815.
  2. Indrevaer RL, et al. 2013. J. Immunol. 191:3624. PubMed
AB_2783186 (BioLegend Cat. No. 312911)
AB_2783187 (BioLegend Cat. No. 312912)

Antigen Details

Member of the toll-like receptor family, 105 kD

B cells, monocytes/macrophages, and dendritic cells

Signaling protein involved in innate immunity
Cell Type
B cells, Dendritic cells, Macrophages, Monocytes
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Miura Y, et al. 1998. Blood 92:2815.

Gene ID
4064 View all products for this Gene ID
View information about CD180 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 10/02/2018

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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