- PMab-1 (See other available formats)
- Regulatory Status
- Other Names
- T1a, gp38, stromal cell marker
- Rat IgG2a, κ
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- Product Citations
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The mucin-type glycoprotein podoplanin is thought to be involved in the development of the lymphatic vascular system. Podoplanin is named after its expression in the kidney glomerular epithelial cells (podocytes). It has a potential role in tumor progression.Product Details
- Antibody Type
- Host Species
- Peptide (38-51 amino acids of mouse podoplanin)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
IHC-F - Quality tested
3D IHC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5.0 - 10 µg/mL is suggested. For 3D immunohistochemistry on formalin-fixed tissues, a concentration of 5.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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(PubMed link indicates BioLegend citation)
- Yamada S, et al. 2017. Monoclon Antib Immunodiagn Immunother. 36(2):77-79.
AB_2800698 (BioLegend Cat. No. 156205)
AB_2819915 (BioLegend Cat. No. 156206)
- 43 kD glycosylated type-1 transmembrane protein. Mucin-type protein.
Expressed on epithelial and mesothelial cells.
- Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation.
- Interacts with CLEC1B; the interaction is independent of CLEC1B glycosylation and activates CLEC1B; the interaction is dependent of sialic acid on O-glycans.
- Cell Type
- Epithelial cells
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
- Antigen References
- Farr A, et al. 1992. J Histochem Cytochem. 40:651.
- Schacht V, et al. 2005. Am J Pathol. 166:913.
- Gene ID
- 14726 View all products for this Gene ID
- View information about Podoplanin on UniProt.org
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