Recombinant Human IL-31 (ELISA Std.)

Pricing & Availability
Regulatory Status
Other Names
Ave. Rating
Submit a Review
Product Citations
  • Human_IL-31_RECOM_ELISA_032717
Cat # Size Price Quantity Check Availability Save
561901 4 pack $88
Check Availability

Need larger quantities of this item?
Request Bulk Quote
This product is scheduled for discontinuation. Please use the availability checker to determine current availability.

IL-31, produced mainly by activated CD4+ T cells, is a newly discovered helical cytokine belonging to the gp130/IL6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune responses. Human IL-31 is also involved in inflammatory bowel disease, airway hypersensitivity, and dermatitis.

Product Details
Technical data sheet

Product Details

E. coli derived Ser24-Thr164.
Molecular Mass
The recombinant protein has a predicted molecular mass of approximately 15.8 kDa.
>95%, as determined by Coomassie stained SDS-PAGE
Lyophilized in sterile-filtered PBS, pH 7.2, containing 1% BSA, 0.09% sodium azide, and protease inhibitors.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
Upon receipt, store unopened vials between 2°C and 8°C immediately and use within 12 months from date of receipt. Prior to use, reconstitute the lyophilized powder with 0.2 ml of PBS containing a carrier protein (e.g., 1% BSA, protease free), pH 7.4. Re-cap vial, vortex. Allow the reconstituted standard to sit at room temperature for 15 minutes, vortex again to mix completely. The reconstituted standard stock solution can be aliquoted into polypropylene vials and stored at -70°C for up to one month. Do not re-use diluted standards. Use a manual defrost freezer and avoid repeated freeze thaw cycles.

ELISA - Quality tested

Recommended Usage

Each lot of this protein is quality control tested by ELISA. For use as an ELISA standard, a standard curve comprised of doubling dilutions from 2000 pg/mL to 31.3 pg/mL is suggested. It is recommended that the reagent be titrated for optimal performance.

Application Notes

This IL-31 protein is useful as a standard for a human IL-31 sandwich ELISA, using unlabeled Poly5300 antibody as capture and biotinylated Poly5300 antibody  as detection.

Antigen Details

161 aa with a putative 23 aa signal peptide that is cleaved to generate a 138 aa mature protein.

Secreted by activated CD4<sup+</sup> T cells.

IL-31 belongs to the IL-6 family of cytokines and plays a role in skin inflammation.
Binds to IL-31 receptor complex that consists of two receptor subunits, IL31RA and OSMR.
Biology Area
Immunology, Innate Immunity, Stem Cells
Molecular Family
Antigen References

1. McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42.
2. Arai I, et al. 2013. Exp. Dermatol. 22:669.
3. Dai X, et al. 2013. PLoS One. 8:e67666.
4. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446.
5. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232.
6. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5.

Gene ID
386653 View all products for this Gene ID
View information about IL-31 on

Related FAQs

There are no FAQs for this product.
Go To Top Version: 0    Revision Date: 03/28/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


8999 BioLegend Way, San Diego, CA 92121
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587


Remember me
Forgot your password? Reset Password
Request an Account