- 9D11A43 (See other available formats)
- Other Names
- XBP-1 isoform2, Tax-responsive element-binding protein 5 (TREB5), XBP2
- Mouse IgG2a, κ
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- Product Citations
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XBP-1 is a transcription factor containing a bZIP domain. It was first identified because of its ability to bind X-box, a conserved transcriptional element in the promoter of the human HLA-DR gene. XBP-1 has multiple functions. It controls MHC class II gene regulation and is also essential for differentiation of plasma cells. XBP-1 is upregulated as part of the ER stress response, also known as the unfolded protein response.Product Details
- Mouse, Cross-Reactivity: Human
- Antibody Type
- Host Species
- Partial mouse XBP-1s recombinant protein (162-267aa)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC, ChIP - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per mL. For ChIP application, use 2 µg of antibody and 10 µg of chromatin per IP. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The clone 9D11A43 recognizes spliced XBP-1 (XBP-1s/isoform 2), which is 371 amino acids and migrates around 55 kD on the SDS-PAGE.
- Additional Product Notes
Using this antibody at a ratio higher than 1:5 (µg antibody per ug of chromatin) will increase background
- Product Citations
AB_2562960 (BioLegend Cat. No. 658802)
- Upregulated by ER stress, IL-6, and IL-4. Downregulation correlates with tumor progression in prostate cancer. Downregulated by PAX5 transcription factor.
- Biology Area
- Cell Biology, Immunology, Transcription Factors
- Molecular Family
- MHC Antigens, Nuclear Markers
- Antigen References
1. Liou HC, et al. 1990. Science 247:1581.
2. Ponath PD, et al. 1993. J. Biol. Chem. 268:17074.
3. Takahashi S, et al. 2002. Prostate 50:154.
- Gene ID
- 7494 View all products for this Gene ID
- View information about XBP-1s on UniProt.org
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