Purified anti-Transthyretin, 31-50 Antibody

Pricing & Availability
Clone
CPTC-TTR-1 (See other available formats)
Other Names
PALB, ATTR, Prealbumin, TBPA
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
CPTC-TTR-1_Pure_Transthyretin_Antibody_1_041018
Western blot of purified anti-Transthyretin antibody (clone CPTC-TTR-1). Lane 1: Molecular weight marker; Lane 2:50 ng of recombinant human transthyretin; Lane 3:80 µg of human plasma; Lane 4:16 µg of human plasma. The blot was incubated with 1.0 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence (Cat. No. 426302) was used as the detection system.
  • CPTC-TTR-1_Pure_Transthyretin_Antibody_1_041018
    Western blot of purified anti-Transthyretin antibody (clone CPTC-TTR-1). Lane 1: Molecular weight marker; Lane 2:50 ng of recombinant human transthyretin; Lane 3:80 µg of human plasma; Lane 4:16 µg of human plasma. The blot was incubated with 1.0 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence (Cat. No. 426302) was used as the detection system.
Cat # Size Price Quantity Avail. Save
853001 25 µg $95
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853002 100 µg $245
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Description

Transthyretin (TTR) is a carrier protein capable of transporting thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. TTR can form aberrant insoluble amyloid fibrils that primarily deposit in a patient’s heart and/or peripheral nerves. The wild-type protein is associated with senile systemic amyloidosis (SSA) and is typically diagnosed in men over 70 years-old. Single or double mutations in TTR are primarily associated with familial amyloidotic polyneuropathy (FAP) or familial amyloid cardiopathy (FAC), affecting younger patients (in their 30s).Clinical symptoms of TTR amyloidosis have historically been attributed to fibrils, but recent experimental evidence indicates that soluble TTR aggregates are also pathogenic.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant Human Transthyretin
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Qulaity tested
Direct ELISA - Validated

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For Direct ELISA applications, a concentration range of 0.002 - 0.2 µg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2728603 (BioLegend Cat. No. 853001)
AB_2728604 (BioLegend Cat. No. 853002)

Antigen Details

Structure
TTR is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 127 amino acids.
Distribution

Tissue sources: Liver, choroid plexus epithelium, and retina pigment epithelium.
Distribution: Primarily extracellular in blood and cerebrospinal fluid.

Function
The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
Interaction
Perlecan, receptor for advanced glycation end product (RAGE)
Ligand Receptor
Thyroxine, retinol-binding protein bound to retinol
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
Carrier Proteins
Antigen References
  1. Plante-Bordeneuve V, et al. 2011. Lancet Neurol. 10:1086. PubMed
  2. Pinney JH, et al. 2013. J Am Heart Assoc. 2:e000098. PubMed
  3. Hawkins PN, et al. 2015. Ann Med. 47(8):625. PubMed
Gene ID
7276 View all products for this Gene ID
UniProt
View information about Transthyretin on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 02/13/2019

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