- TA5F4 (See other available formats)
- Other Names
- PALB, ATTR, Prealbumin, TBPA, TTR
- Mouse IgG1, κ
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- Product Citations
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Transthyretin (TTR) is a carrier protein capable of transporting thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. TTR can form aberrant, insoluble amyloid fibrils that primarily deposit in a patient's heart, peripheral nerves, or both. The wild-type protein is associated with senile systemic amyloidosis (SSA) and is typically diagnosed in men over 70-years-old. Single or double mutations in TTR are primarily associated with familial amyloidotic polyneuropathy (FAP) or familial amyloid cardiopathy (FAC) which affects younger patients, often in their 30s. Clinical symptoms of TTR amyloidosis have historically been attributed to fibrils, but recent experimental evidence indicates that soluble TTR aggregates are also pathogenic.Product Details
- Antibody Type
- Host Species
- A 1:1 mixture of wild-type Transthyretin fibrils and soluble aggregates of Y78F TTR.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ELISA Capture - Quality tested
IHC-P - Validated
Direct ELISA - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration of 2.0 µg/ml is recommended. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, a concentration of is 1.0 - 5.0 µg/ml is recommmended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone TA5F4 recognizes an epitope on aggregated transthyretin that encompasses mid- and N-terminal regions.
(PubMed link indicates BioLegend citation)
- Phay M, et al. 2014. Rejuvenation Res. 17(2):97. (Direct ELISA, Capture ELISA, IHC) PubMed
AB_2632815 (BioLegend Cat. No. 848101)
AB_2632816 (BioLegend Cat. No. 848102)
- Transthyretin (TTR) is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 127 amino acids.
- Primarily extracellular in blood and cerebrospinal fluid.
- The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
- Perlecan, receptor for advanced glycation end product (RAGE).
- Ligand Receptor
- Thyroxine, retinol-binding protein bound to retinol.
- Cell Sources
- Liver, choroid plexus epithelium, retina pigment epithelium.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Carrier Proteins
- Antigen References
- Gene ID
- 7276 View all products for this Gene ID
- View information about Transthyretin, aggregated on UniProt.org
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