- W17122A (See other available formats)
- Regulatory Status
- Other Names
- C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase, Protein-Glutamine Gamma-Glutamyltransferase 2, Transglutaminase C, Transglutaminase H, Tissue Transglutaminase, Transglutaminase 2
- Rat IgG2a, κ
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- Product Citations
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Transglutaminase 2 (TGM2) is a multifunctional enzyme required for diverse cellular processes, including cell death, differentiaton, apoptosis, and cell migration. TGM2 catalyzes the crosslinking through calcium-activated transamidation of available glutamine and lysine residues on substrate proteins. TGM2 also has GTPase and ATPase activity; transamidation activity is allosterically inhibited by guanine nucleotide binding. It is essential for cancer stem cell survival and is a chemotherapy resistance factor.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Partial human recombinant human TGM2 protein corresponding to amino acids 1-250.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone was tested for ICC using PFA-fixed A431 cells permeabilized with Triton X-100 or methanol. Staining in the incorrect subcellular compartment was observed using each method; we therefore do not recommend this clone for ICC.
This clone failed to immunoprecipitate TGM2 during PD testing.
AB_2810665 (BioLegend Cat. No. 616601)
AB_2810666 (BioLegend Cat. No. 616602)
- TGM2 is a 687 amino acid protein with a predicted molecular weight of 77 kD.
Tissue enriched/cytosol localization
- Post translational modification, GTPase activity.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Structure
- Molecular Family
- Enzymes and Regulators
- Gene ID
- 7052 View all products for this Gene ID
- View information about TGM2 on UniProt.org
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