- A17106C (See other available formats)
- Other Names
- Transcription factor EB
- Mouse IgG2a, λ
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- Product Citations
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The autophagy-lysosomal pathway is involved in the degradation of long-lived proteins. The transcription factor EB (TFEB) plays a critical role in regulating basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR)-mediated phosphorylation. TFEB is also involved in physiological processes, and it induces the intracellular clearance of pathogenic factors in a variety of diseases, such as Parkinson's and Alzheimer's, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2728585 (BioLegend Cat. No. 852001)
AB_2728586 (BioLegend Cat. No. 852002)
- TFEB is a 476 amino acid protein with a molecular weight mass of approximately 53kD.
Tissue distribution: TFEB is expressed in numerous cell types of the central nervous system (CNS).
Cellular distribution: Cytosolic and nucleus.
- TFEB is a major regulator of autophagy and lysosomal biogenesis.
- TFEB interacts with the mTOR complex and its activity is thought to be regulated through the phosphorylation by mTOR.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
- Martini-Stoica H, et al. 2016. Trends Neurosci. 221-234.
- Napolitano G, Ballabio A. 2016. J. Cell Sci. 129: 2475-81.
- Raben N, Puertollano R. 2016. Annu. Rev. Cell Dev. Biol. 32: 255-278.
- Gene ID
- 7942 View all products for this Gene ID
- View information about TFEB on UniProt.org
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