- Tau-nY18 (See other available formats)
- Other Names
- Microtubule-associated protein tau, PHF-tau, paired helical filament-tau, neurofibrillary tangle protein, microtubule-associated protein tau, isoform 4, G protein beta1/gamma2 subunit-interacting factor 1
Covance Catalog# SIG-39436
- Mouse IgG2b, κ
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- Product Citations
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Tau proteins are microtubule-associated protein (MAPs) which are abundant in neurons of the central nervous system, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes and elsewhere. One of tau's main functions is to modulate the stability of axonal microtubules. Tau is active primarily in the distal portions of axons providing microtubule stabilization as well as flexibility. Pathologies and dementias of the nervous system such as Alzheimer's disease feature tau proteins that have become defective and no longer stabilize microtubules properly. As a result, tau forms aggregates with specific structural properties referred to as Paired Helical Filaments (PHFs) that are a characteristic of many different types of dementias, known as tauopathies.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution; no preservatives or carrier proteins.
- The antibody was purified by affinity chromatography.
- 1 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
IHC-P - Quality tested
WB, ELISA - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is specific for Tau nitrated at Tyr18. It does not cross react with wild type tau, or tau nitrated at Tyr 29, Tyr 197, or Tyr 394.
(PubMed link indicates BioLegend citation)
- Reyes J., et al. Selective Tau Tyrosine Nitration in Non-AD Tauopathies. Acta Neuropathol 123(1): 119-132, 2012.
- Reyes J., et al. A Possible Link Between Astrocyte Activation and Tau Nitration in Alzheimer's Disease. Neurobiol Dis 31(2): 198-208, 2008.
- Reynolds M., et al. Tau Nitration Occurs at Tyrosine 29 in the Fibrillar Lesions of Alzheimer's Disease and Other Tauopathies. J Neurosci 26(42): 10636-10645, 2006.
- Reyes JF, et al. 2008. Neurobiol. Dis. 31:198. (ELISA, WB IHC)
- Reyes JF, et al. 2012. Acta. Neuropathol. 123:119. (WB, IHC, ELISA)
AB_2721757 (BioLegend Cat. No. 829703)
AB_2564931 (BioLegend Cat. No. 829701)
- Cell Type
- Embryonic Stem Cells
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Stem Cells
- Molecular Family
- Gene ID
- View information about Tau Nitrated (Tyr18) on UniProt.org
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