- N277/7 (See other available formats)
- Other Names
- Synaptotagmin-12, sytXII, synaptotagmin 12, Syt12, Synaptotagmin XII, Synaptotagmin-related gene 1 protein, Srg1, Sytr1
Covance Catalog# MMS-5197
- Mouse IgG1
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Synaptotagmin 12 (Syt12) is regulated by protein kinase A (PKA) and is unique from other synaptotagmins in that it does not bind to Ca2+. Syt12 interaction with Syt1 prevents SNARE complex binding. Expression of Syt12 induces spontaneous neurotransmitter release, providing a mechanism for spontaneous synaptic-vesicle exocytosis that is Ca2+-independent.Product Details
- Mouse, Rat, Human
- Host Species
- This monoclonal antibody was raised against a fusion protein corresponding to amino acids 168-255 (cytoplasmic C2A domain) of mouse Synaptotagmin-12.
- Phosphate-buffered solution with BSA + 0.1% NaN3.
- The antibody was purified by affinity chromatography.
- 1 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting.
The optimal working dilution should be determined for each specific assay condition.
• WB: 2 - 10 µg/ml
• IHC: 10 µg/ml
Tissue: Formalin-fixed Paraffin-embedded
Primary incubation: 24 hours at 2-8°C
- Application Notes
This antibody is effective in immunoblotting (WB) and immunohistochemistry (IHC).
*Expected MW: 47 kD
WB Positive Control: Brain membrane lysates from human, mouse and rat
IHC Positive Control: Rat and mouse brain
AB_2564840 (BioLegend Cat. No. 820401)
- Gene ID
- View information about Synaptotagmin-12 on UniProt.org
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