- Poly6511 (See other available formats)
- Other Names
- Signal transducer and activator of transcription 5 (STAT5), MGF
- Rabbit Polyclonal IgG
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- Product Citations
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STAT5 has gene transactivation activity and plays a key role in lymphocyte differentiation and proliferation. Tyrosine phosphorylation of STAT5, induced by cytokine stimulation, results in dimerization through its SH2 domains. The dimerized STAT5 proteins translocates from the cytoplasm to the nucleus and subsequently regulates gene transcription.Product Details
- Antibody Type
- Host Species
- Modified synthetic peptide
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
- The antibody was purified by affinity chromatography.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- Upon receipt, store undiluted at -20°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The STAT5 phospho-tyr694 antibody recognizes the regulatory tyrosine phosphorylation of human STAT5 protein and has been shown to be useful for Western blotting.
This product may contain other non-IgG subtypes.
AB_10896060 (BioLegend Cat. No. 651101)
AB_10900416 (BioLegend Cat. No. 651102)
- STAT5 exists in two isoforms, STAT5A and STAT5B, which consists of an N-terminal dimerization domain, a SH2 domain, a regulatory tyrosine (Y694 and Y699 in the case of STAT5A and STAT5B, respectively) responsible for binding of SH2 domain, and a C-termina
Cytoplasm. Translocates to nucleus in response to tyrosine phosphorylation.
- STAT5 is a transcription regulator and is involved in cell differentiation, proliferation, and survival, in response to several cytokines, such as interleukins, erythropoietin, growth hormone, thrombopoietin, and prolactin.
- Histone acetyltransferases CBP and p300; SMRT.
- Biology Area
- Cell Biology, Transcription Factors
- Molecular Family
- Phospho-Proteins, Nuclear Markers
- Antigen References
1. Teglund S, et al. 1998. Cell 93:841.
2. Moriggl R, et al. 1999. Immunity 10:249.
3. Peschon JJ, et al. 1994. J. Exp. Med. 180:1955.
4. Lynn M, et al. 2011. Ann. N.Y. Acad. Sci. 1217:18.
5. Malin S, et al. 2010. Curr. Opin. Immunol. 22:168.
- Gene ID
- 6777 View all products for this Gene ID
- View information about STAT5 Phospho Tyr694 on UniProt.org
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