- A20016A (See other available formats)
- Regulatory Status
- Other Names
- CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3, Syp, Protein Tyrosine Phosphatase Non-Receptor Type 11, SH2 Domain-Containing Protein Tyrosine Phosphatase 2
- Mouse IgG1, κ
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- Product Citations
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Src homology-2-containing protein tyrosine phosphatase 2 (SHP-2) protein, encoded by PTPN11 gene, is a well-known oncogenic protein tyrosine phosphatase. SHP-2 regulates cellular functions by dephosphorylating targets downstream of PD1, EGFRvIII, HGF receptor, and cytokine receptors. Cellular processes controlled by SHP-2 include mitotic cycle, cell growth, differentiation, and oncogenesis. SHP-2 has been recognized as a potential therapeutic target for cancers including breast cancer, lung cancer, leukemia, gastric cancer, and oral cancer.Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Host Species
- Synthetic peptide from human SHP-2
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody recognizes endogenous human and mouse SHP-2 proteins in K-562, HeLa, HEK293, and NIH/3T3 cell lysates by WB.
AB_2894536 (BioLegend Cat. No. 948201)
AB_2894536 (BioLegend Cat. No. 948202)
- SHP-2 is a 593 amino acid protein with a molecular mass of 68 kD.
Cytoplasm and Nucleus
- SHP-2 regulates cell proliferation, apoptosis, invasion, and metastasis.
- SHP-2 interacts with PD1, EGFR, HGF receptor, RET, FGFR2, FGFR3, PI3K/AKT, and TLR3 signaling pathways.
- Cell Type
- Lymphocytes, T cells, Th1
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Immuno-Oncology, Immunology
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
- Hao C, et al. 2020. Oncogene. 39:7166-7180.
- Marie D., et al. 2008. Cell Signal. 20:453-9.
- Cheng Kui QU. 2000. Cell Research. 10:279-288.
- Gene ID
- 5781 View all products for this Gene ID
- View information about SHP-2 on UniProt.org
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