- A16007A (See other available formats)
- Other Names
- NRGN, Ng, RC3, Calmodulin-Binding Protein, Protein Kinase C Substrate, Hng
- Mouse IgG2b, κ
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Neurogranin (NRGN) is the main post-synaptic protein kinase substrate that binds to calmodulin (CaM) in the absence of calcium. It is suggested that NRGN is a direct target for thyroid hormone in the human brain, and that the control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. Neurogranin in CSF has been implicated as a possible marker for synaptic degeneration in Alzheimer’s disease.Product Details
- Human, Rat
- Antibody Type
- Host Species
- KLH conjugated synthetic peptide corresponding to amino acid residues 70-78 of human neurogranin protein.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ELISA Capture, IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2650691 (BioLegend Cat. No. 848501)
AB_2650692 (BioLegend Cat. No. 848502)
- Neurogranin is a 78 amino acid protein with a molecular mass of approximately 7.6 kD.
Tissue Distribution: Cerebral cortex neurons in layers II-VI, and pyramidal neurons.
Cellular distribution: Golgi apparatus, mitochondria, nucleus, and cytoplasm in neuronal cell body and dendrites.
- Neurogranin is a neuron-specific, calmodulin-binding protein that participates in the protein kinase C signaling pathway. Neurogranin is a post-synaptic protein that modulates Ca2+ homeostasis in neurons by binding to and regulating the availability of calmodulin in the absence of Ca2+. Neurogranin function has been implicated in learning and memory.
- Ligand Receptor
- Cell Type
- Biology Area
- Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
- Molecular Family
- Postsynaptic proteins
- Antigen References
- Gene ID
- 4900 View all products for this Gene ID
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