Purified anti-mouse TCR Vβ8.1, 8.2 Antibody

Pricing & Availability
MR5-2 (See other available formats)
Other Names
T cell receptor beta 8
Mouse IgG2a, κ
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Product Citations
BALB/c splenocytes stained with purified MR5-2 conjugated with PE and CD3 APC
  • MR5-2_PE_060710
    BALB/c splenocytes stained with purified MR5-2 conjugated with PE and CD3 APC
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140102 100 µg $185
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Vβ8 T cell receptor (TCR Vβ8) subfamily has three members, Vβ8.1, 8.2, and 8.3. These subfamily members are variants of the TCR β chain that along with the TCR α chain forms the TCR heterodimer, responsible for the recognition of peptides presented by the MHC molecules. Murine Vβ8+ T cells recognize the superantigen staphylococcal enterotoxin B (SEB); in vivo administration of SEB results in the negative selection of Vβ8+ cells in the thymus. Vβ8 is one of the most frequently found β chains on the infiltrating T cells in the brain of mice with experimental autoimmune encephalomyelitis (EAE), and on the T cells response to Toxoplasma gondii.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
H-Y specific TH Clone OI6
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested
IHC - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: induction of proliferation of Vβ8.1+ and Vβ8.2+ T cells1,2 and immunohistochemical staining3.

Application References

(PubMed link indicates BioLegend citation)
  1. Kanagawa OJ. 1988. J. Immunol. Methods 110:169. (Activ)
  2. Denkers EY, et al. 1986. J. Immunol. 156:1089. (Activ)
  3. Drescher KM, et al. 2000. Int. Immunol. 12:271. (IHC)
AB_10645511 (BioLegend Cat. No. 140102)

Antigen Details

Members of the immunoglobulin superfamily, Vβ8.1 and 8.2 are variants of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.
Expressed in a subset of TCR αβ+ T cells
Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune response
MHC-Peptide complex
Cell Type
T cells
Biology Area
Immunology, Adaptive Immunity
Molecular Family
Antigen References

1. Marrack P, et al. 2008. Annu. Rev. Immunol. 26:171.
2. Acha-Orbea H and MacDonald HR. 1995. Annu. Rev. Immunol. 13:459.
3. Sim GK and Augustin AA. 1985. Cell 42:89.
4. Mami-Chouaib F, et al. 2002. Immunol. Rev. 188:114.

Gene ID
21577 View all products for this Gene ID
View information about TCR V beta 8 on UniProt.org

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Go To Top Version: 2    Revision Date: 02/05/2014

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