Purified anti-mouse IL-17RB Antibody

Pricing & Availability
Clone
9B10 (See other available formats)
Other Names
Evi27, IL-17ER, IL17RH1, IL17br, IL-17 receptor B
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
9B10_Purified_IL-17RB_Antibody_FC_080113
Mouse IL-17RB transfected 300.19 cells were stained with purified IL-17RB (clone 9B10, filled histogram) or rat IgG2a, κ (open histogram), followed by anti-rat IgG PE.
  • 9B10_Purified_IL-17RB_Antibody_FC_080113
    Mouse IL-17RB transfected 300.19 cells were stained with purified IL-17RB (clone 9B10, filled histogram) or rat IgG2a, κ (open histogram), followed by anti-rat IgG PE.
Cat # Size Price Quantity Avail. Save
146302 100 µg $225
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Description

IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family.  IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.  It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.  It binds IL-17B and IL-17E (IL-25) but not IL-17A or C.  Its interaction with IL-25 has a higher affinity than that with IL-17B.  Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.  IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse IL-17RB - Fc chimera (human IgG1)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2562379 (BioLegend Cat. No. 146302)

Antigen Details

Structure
Single pass type I transmembrane protein, 55.9 kD
Distribution
iNKT cells, innate lymphoid cells, Th2 cells
Function
Binds IL-25 with higher affinity than IL-17B, can block IL-25 mediated pathology
Interaction
TRAF6 and Act1
Ligand/Receptor
IL-25/IL-17E
Cell Type
NKT cells, Th2
Biology Area
Immunology, Innate Immunity
Molecular Family
Cytokine/Chemokine Receptors
Antigen References

1. Hwang SY, et al. 2004. Arthritis Res. Ther. 6:R120.
2. Rickel EA, et al. 2008. J. Immunol. 181:4299.
3. Terashima A, et al. 2008. J. Exp. Med. 205:2727.

Gene ID
50905 View all products for this Gene ID
UniProt
View information about IL-17RB on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 09/23/2013

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