Purified anti-mouse CD335 (NKp46) Recombinant Antibody

Pricing & Availability
Clone
QA17A25 (See other available formats)
Regulatory Status
RUO
Other Names
NKp46, NCR1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA17A25_PURE_-CD335_Antibody_2_121321
C57BL/6 mouse splenocytes were stained with purified anti-mouse CD335 NKp46 (clone QA17A25) (left) or mouse IgG1, κ isotype control (right), followed by anti-mouse IgG1 PE. Cells were then costained with anti-mouse NK1.1 APC.
  • QA17A25_PURE_-CD335_Antibody_2_121321
    C57BL/6 mouse splenocytes were stained with purified anti-mouse CD335 NKp46 (clone QA17A25) (left) or mouse IgG1, κ isotype control (right), followed by anti-mouse IgG1 PE. Cells were then costained with anti-mouse NK1.1 APC.
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157402 500 µg $314
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Description

CD335, also known as NKp46, is a single-pass type I membrane protein of 46 kD. It belongs to the natural cytotoxicity receptor (NCR) family and contains two Ig-like (immunoglobulin-like) domains. Its expression is restricted to NK cells and a subset of NKT cells; it is not expressed in CD1d-restricted NKT cells. CD335 is a receptor for viral hemagglutinins and heparan sulfate proteoglycans and is involved in NK cell activation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Mouse
Immunogen
NKp46-IgG1 Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Additional Product Notes
Clone QA17A25 is able to block the binding of clone 29A1.4, and vice versa.
RRID
AB_2904298 (BioLegend Cat. No. 157402)

Antigen Details

Structure
Single-pass type I membrane protein, 46 kD; belongs to the natural cytotoxicity receptor (NCR) family; contains 2 Ig-like (immunoglobulin-like) domains
Distribution

Mature and immature NK cells, subset of NKT cells, but not on CD1d-restricted NKT cells

Function
NK cells activation
Ligand/Receptor
Viral hemagglutinins, heparan sulfate proteoglycans
Antigen References
  1. Colucci F and Cilio CM. 2010. Nat Immunol. 11:111-2.
  2. Caligiuri MA. 2008. Blood. 112:461-9.
  3. Colonna M. 2009. Immunity. 31:15-23.

 

Gene ID
17086 View all products for this Gene ID
UniProt
View information about CD335 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 12/13/2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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  • Purified anti-mouse CD335 (NKp46) Recombinant Antibody

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