- MC.028.83.76.242 (See other available formats)
- Regulatory Status
- Other Names
- Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid arthritis 17, AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Covance Catalog# SIG-39840
- Mouse IgG1
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- Product Citations
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Leucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.Product Details
- Antibody Type
- Host Species
- This monoclonal antibody was raised against a peptide immunogen comprising amino acids 2069-2087 of the LRRK2 protein in mice that did not express endogenous LRRK2 protein.
- Phosphate-buffered solution.
- The antibody was purified by affinity chromatography.
- 1 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
IHC-P - Quality tested
Direct ELISA - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 25 µg/mL is suggested. For Direct ELISA, a concentration range of 1.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody was generated with support from The Michael J. Fox Foundation. The Michael J. Fox Foundation is dedicated to finding a cure for Parkinson's disease through an aggressively funded research agenda and to ensuring the development of improved therapies for those living with Parkinson's today. To learn more about MJFF, please visit www.michaeljfox.org.
AB_2564739 (BioLegend Cat. No. 808201)
- This gene is a member of the leucine-rich repeat kinase family and is encoded by the PARK8 gene. The protein is present mainly in the cytoplasm but can be associated with the mitochondrial outer membrane.
Tissue distribution: Lung, Kidney, parathyroid gland, CNS
Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome
- LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.
- Biology Area
- Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Mitochondrial Markers
- Antigen References
- Paisán-Ruíz C, et al. 2004. Neuron. 44(4):595-600.
- Alegre-Abarrategui J, et al. 2009. Hum. Mol. Genet. 18(21):4022-34.
- Gómez-Suaga P, et al. 2012. Hum. Mol. Genet. 21(3):511–25.
- Orenstein SJ, et al. 2013. Nat. Neurosci. 16(4):394–406.
- Cherra SJ, et al. 2013. Am. J. Pathol. 182(2):474–84.
- Gene ID
- 120892 View all products for this Gene ID
- View information about LRRK2 on UniProt.org
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