- WL4G10 (See other available formats)
- Regulatory Status
- Other Names
- CMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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Lamins A and C are structural components of the lamina, a scaffold of proteins localized to the nuclear inner membrane, and contribute to nuclear membrane dynamics and chromatin structure. Mutations in the LMNA gene have been linked to multiple laminopathy disorders, including Hutchinson-Gilford progeria syndrome (HGPS), an autosomal dominant disorder characterized by the appearance of accelerated and dramatic aging. Patients with HGPS have a mutation in the LMNA gene that results in aberrant splicing and production of the toxic, truncated Lamin A protein progerin that functions in a dominant negative pattern.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- GST fused to C-terminal fragment of Lamin A (amino acid residues 422-664)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
WL4G10 does not recognize mouse Lamin A or C.
WL4G10 failed to immunoprecipitate Lamin A or C from HeLa lysates.
During PD testing for ICC applications, WL4G10 staining of PFA-fixed HeLa cells was compatible with both Methanol and Triton X-100 permeabilization methods; observed staining was slightly better with Triton X-100 permabilization.
AB_2810655 (BioLegend Cat. No. 600001)
AB_2810656 (BioLegend Cat. No. 600002)
- Lamin A is a 664 amino acid protein with a predicted molecular weight of 74 kD. Lamin C is a 572 amino acid protein with a predicted molecular weight of 65 kD.
Ubiquitously expressed/Nucleoplasmic side of inner nuclear membrane
- Fibrous component of nuclear lamina, provides framework for nuclear envelope, may interact with chromatin
- Cell Type
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers, Western Blot Controls
- Molecular Family
- Nuclear Markers, Organelle Markers
- Gene ID
- 4000 View all products for this Gene ID
- View information about Lamin A/C on UniProt.org
|Purified anti-Lamin A/C||WL4G10||WB, ICC|
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