Purified anti-human TMPRSS11E (DESC1) Antibody

Pricing & Availability
Clone
TM191 (See other available formats)
Other Names
Transmembrane protease serine 11E, TMPRSS11E2, differentially expressed in squamous cell carcinoma 1, DESC1
Isotype
Mouse IgG1, κ
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Product Citations
publications
TM19_PURE_TMPRSS11E_1_082517
TMPRSS11E transfected BAF3 cells were stained with purified anti-TMPRSS11E (Clone TM191, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE
  • TM19_PURE_TMPRSS11E_1_082517
    TMPRSS11E transfected BAF3 cells were stained with purified anti-TMPRSS11E (Clone TM191, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE
  • TM19_PURE_TMPRSS11E_2_082517
    Metastatic colorectal adenocarcinoma Colo205 cells were stained with purified anti-TMPRSS11E (Clone TM191, filled histogram) or purified mouse IgG1,κ isotype control (open histogram), followed by anti-mouse IgG PE.
Cat # Size Price Quantity Avail. Save
392002 100 µg $225
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Description

TMPRSS11E also called DESC1 is a type II transmembrane serine protease. It is a tumor suppressor to sensitize cell apoptosis through downregulation of the EGFR/AKT pathway.  Expression of TMPRSS11E may be involved in up/down regulation for a particular protease among different types of cancers. TMPRSS11E gene expression is shown to be reduced or absent in squamous cell carcinoma, while overexpression of the gene has been seen in kidney, brain and breast cancer carcinomas. It has been reported that cells forced to express TMPRSS11E have an increased ability of cellular infiltration.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified recombinant TMPRSS11E.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2715790 (BioLegend Cat. No. 392002)

Antigen Details

Distribution

Epithelial cells. Tissue-specific expression occurs from the head and neck, skin, prostate and testes.

Function
Serine protease which has gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.
Interaction
Extracellular region (Ser159-IIE423).
Cell Type
Epithelial cells
Biology Area
Cancer Biomarkers, Cell Biology
Antigen References

1.Lang JC, et al. 2001. Br J Cancer. 84(2):237
2. Ng HY, et al. 2016. Int J Cancer. 138(12):294
3. Viloria C G, et al. 2007. Br J Cancer. 97(2): 201
4. Sedghizadeh PP. et al. 2006. Head Neck. 28(5):432
5. Behrens M. et al. 2004. 61(22):2866

Gene ID
28983 View all products for this Gene ID
UniProt
View information about TMPRSS11E on UniProt.org

Related FAQs

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Go To Top Version: 0    Revision Date: 08/28/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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