- LpMab-21 (See other available formats)
- Other Names
- T1a, T1a2, gp36, gp38, gp40, Aggrus, PDPN, D2-40
- Mouse IgG2a, κ
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- Product Citations
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Podoplanin is a 40-43 kD type-I transmembrane sialomucin-type glycoprotein, also known as T1a, gp36, gp38, gp40, and Aggrus. Originally detected on the surface of podocytes, futher characterization showed podoplanin has a broad tissue distribution, including mesothelial cells, epithelial cells, follicular dendritic cells, and a variety of tumor cells. It has been reported that podoplanin is the ligand of CLEC2 and is involved in lymphatic vessel formation, platelet aggregation, and tumor metastasis. Podoplanin may serve as a useful marker for tumor diagnosis and prognosis.Product Details
- Antibody Type
- Host Species
- Recombinant human podoplanin
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Kaneko MK, et al. 2017. Cancer Med. 6(2):382-396 (IHC-P, FC)
AB_2750203 (BioLegend Cat. No. 395002)
- 40-43 kD type-I transmembrane sialomucin-type glycoprotein
Broad tissue distribution, including mesothelial cells, epithelial cells, follicular dendritic cells, and many tumor cells
- Lymphatic vessel formation, tumor metastasis, platelet aggregation
- Ligand Receptor
- Antigen References
- Raica M, et al. 2008. Anticancer Res. 28:2997.
- Xie Q, et al. 2008. Int. J. Clin. Exp. Pathol. 1:276.
- Ogasawara S, et al. 2008. Hybridoma. 27:259.
- Kato Y, et al. 2003. J. Biol. Chem. 278:51599.
- Gene ID
- 10630 View all products for this Gene ID
- View information about Podoplanin on UniProt.org
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