Purified anti-human/mouse Integrin β7 Antibody

Pricing & Availability
FIB504 (See other available formats)
Regulatory Status
VI 6T-101, VI A024
Other Names
β7 Integrin, integrin βp, ITGB7
Rat IgG2a, κ
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Product Citations
Human peripheral blood lymphocytes stained with purified FIB504, followed by anti-mouse IgG FITC
  • FIB504_Purified_073007
    Human peripheral blood lymphocytes stained with purified FIB504, followed by anti-mouse IgG FITC
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321202 100 µg $114
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Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via interaction with its ligand E-Cadherin.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human, Mouse, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Chimpanzee
Antibody Type
Host Species
TK1 cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The FIB504 antibody has been reported to react with mouse and human ß7 integrin and to block ß7 integrin-mediated cell adhesion in in vitro and in vivo studies. Additional reported applications (for the relevant formats) include: blocking of cell adhesion1,3,4. The Ultra-LEAF™ purified FIB504 antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 321233-321238).

Application References

(PubMed link indicates BioLegend citation)
  1. Andrew DP, et al. 1994. J. Immunol. 153:3847. (Block)
  2. Berlin C, et al. 1993. Cell 74:185.
  3. Rott LS, et al. 1996. J. Immunol. 156:3727. (Block)
  4. Rivera-Nieves J, et al. 2005. J. Immunol. 174:2343. (Block)
  5. Ohmori K, et al. 2009. J. Immunol. 182:2835. PubMed
  6. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
Product Citations
  1. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  2. Eccles JD, et al. 2020. Cell Rep. 30:351. PubMed
  3. Tan X, et al. 2011. J Virol. 85:8316. PubMed
  4. Chng MHY, et al. 2020. Immunity. 51(6):1119-1135.e5.. PubMed
  5. Hegewisch-Solloa E, et al. 2021. J Immunol. 207:950. PubMed
  6. Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
AB_571975 (BioLegend Cat. No. 321202)

Antigen Details

Integrin family, Ig superfamily, 130 kD, heterodimer with CD49d or CD103

CD49d/β7: majority of lymphocytes, thymocyte subset, and some bone marrow progenitors; CD103/β7: intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, subset of CD8 T cells in lymph nodes

Lymphocyte adhesion, hematopoietic progenitor cells migration
CD49d/β7: VCAM-1 (CD106), MAdCAM-1 and fibronectin; CD103/β7: E-cadherin
Cell Type
Dendritic cells, Hematopoietic stem and progenitors, Lymphocytes, T cells, Thymocytes, Tregs
Biology Area
Cell Biology, Immunology, Neuroscience, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Andrew DP, et al. 1994. J. Immunol. 153:3847.
2. Picarella D, et al. 1997. J. Immunol. 158:2099.
3. Lefrancois L, et al. 1994. Eur. J. Immunol. 24:635
4. Cepek KL, et al. 1994. Nautre 372:190.

Gene ID
16421 View all products for this Gene ID 3695 View all products for this Gene ID
View information about Integrin beta7 on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 08/25/2022

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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