Purified anti-human MERTK Antibody

Pricing & Availability
Clone
590H11G1E3 (See other available formats)
Other Names
C-Mer Proto-Oncogene Tyrosine Kinase, c-mer, Proto-Oncogene C-Mer, MER Receptor Tyrosine Kinase, STK Kinase, Receptor Tyrosine Kinase MerTK, Tyrosine-Protein Kinase Mer, MER, RP38, c-Eyk, Tyro12
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
590H11G1E3_PURE_MERTK_Antibody_FC_1_052915
Human monocytes were stimulated and cultured with M-CSF for seven days and stained with CD11b APC and purified human MERTK (clone 590H11G1E3, top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG PE antibody.
  • 590H11G1E3_PURE_MERTK_Antibody_FC_1_052915
    Human monocytes were stimulated and cultured with M-CSF for seven days and stained with CD11b APC and purified human MERTK (clone 590H11G1E3, top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG PE antibody.
  • 590H11G1E3_PURE_MERTK_Antibody_FC_2_052915
Cat # Size Price Quantity Avail. Save
367602 100 µg $235
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Description

MERTK plays a role in the retinal pigment epithelium as a regulator of rod outer segments fragments phagocytosis. MERTK also plays a role in the inhibition of Toll-like receptor-mediated innate immune responses through the activation of STAT1. Upregulation of MERTK seems to also promote the survival of certain cancer cells, such as t(1;19)-positive acute lymphoblastic leukemias (ALL). MERTK also has a role in cellular migration, as MERTK KO macrophages demonstrate cytoskeletal disruptions that impacts its shape and directional migration. Melanoma cells express high levels of MERTK, which makes this molecule an attractive therapeutic target.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
MERTK extracellular domain/Fc fusion.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Rogers AE, et al. 2012. Oncogene 31:4171.
Product Citations
  1. Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed
RRID
AB_2565898 (BioLegend Cat. No. 367602)

Antigen Details

Structure
Transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain.
Distribution

Macrophages, monocytes, and dendritic cells.

Function
TLR regulation, efferocytosis, phagocytosis regulation, cell survival, and macrophage migration.
Interaction
GRB2, PLCG2, and TNK2.
Ligand/Receptor
LGALS3, TUB, TULP1, and GAS6.
Cell Type
Dendritic cells, Macrophages, Monocytes
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Costimulatory Molecules
Molecular Family
Protein Kinases/Phosphatase, Toll Like Receptors
Antigen References

1. Schlegel J, et al. 2013. J. Clin. Invest. 123:2257.
2. Chen J, et al. 1997. Oncogene 14:2033.
3. Yefimova MG, et al. 2013. Autophagy 9:653.
4. Zhang W, et al. 2013. J. Med. Chem. 56:9693.
5. Lee YJ, et al. 2012. J. Leuko. Biol. 91:921.
6. Krause S, et al. 2015. Blood 125:820.
7. Tang Y, et al. 2015. PLoS One 10:e0117787.

Gene ID
10461 View all products for this Gene ID
UniProt
View information about MERTK on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05/31/2015

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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